Cover Illustration – Molecular Cell

Acrylic and ink on canvas
Original Illustration

Cover of Molecular Cell
10 July, 2009
Volume 35, Issue 1

Illustrating Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA
By Edwin Antony, Eric J. Tomko, Qi Xiao, Lumir Krejci, Timothy M. Lohman, Tom Ellenberger

“Srs2 (blue) clears Rad51 filaments from ssDNA to downregulate homologous recombination. A specific interaction with Srs2 allosterically triggers ATP hydrolysis within the Rad51 filament, causing it to dissociate.”